Chemical constituents of the leaves of Sarcosperma angustifolium Gagnep

Chemical constituents of the leaves of Sarcosperma angustifolium Gagnep

Abstract

One new triterpene saponin (1) and ten known compounds (211) were isolated from the leaves of Sarcosperma angustifolium Gagnep by various chromatography methods. The structures of 111 were determined to be 3-Oβ-D-apiofuranosyl-(1→2)-β-D-glucuropyranosyl-oleanolic acid 28-Oβ-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1), 3′′′-O-de-β-D-apiofuranosylisoarganin F (2), ehretioside B (3), methyl benzoate 2-Oα-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (4), icariside E3 (5), 1-Oβ-D-glucopyranosyl-2-{2,6-dimethoxy-4-[1-(E)-propen-3-ol]phenoxyl}propan-3-ol (6), (7S,8S)-threo-4,7,9-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9′-Oβ-D-glucopyranoside (7), icariside F2 (8), (6S,9S)-roseoside (9), (+)-epicatechin (10), and syringic acid (11). Compounds 3 and 4 showed NO production inhibitory activity in LPS stimulated RAW 264.7 cells with IC50 values of 86.7 and 82.3 µm, respectively.

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